What this is?
This tool surfaces statistically-significant co-occurring conditions observed in a large canine cohort and, where available, directional sequences reported in the literature. It’s designed to support clinical awareness—what else to consider when a patient presents with a known condition.
How to use it...
- Search a condition (e.g., Chronic vomiting, Atopic dermatitis, Hypertension).
- Browse Associated conditions ranked by statistical evidence.
- Toggle Life stage to focus on Young / Mature / Senior dogs (size-adjusted stages).
- Use filters to show stronger signals (e.g., q≤0.05, higher Obs/Exp).
- Check Literature-supported sequences for a small subset with published directional evidence.
What it shows…
- For each starting condition, the most frequent co-conditions and how much more often they occur than expected (Obs/Exp).
- A badge when a pair appears in age-stratified networks.
- Directional pairs from the literature when available (e.g., A often followed by B).
What it’s not…
- Not a diagnostic classifier and not a substitute for clinical judgment.
- Based on owner-reported data (possible misclassification and timing lag).
- Associations were adjusted for key covariates in the paper, but this tool displays pairwise signals only.
Associated conditions
| Associated condition | Category | Adj. p | −log10(q) | Observed | Expected | Obs − Exp | Obs/Exp | In age‑strat network |
|---|
Literature‑supported sequences (12 mo)
| Often followed by… | Citation |
|---|
| Often preceded by… | Citation |
|---|
See all literature examples
Try these examples
- Atopic dermatitis → skin infections, pruritus, contact dermatitis
- Hypertension → consider renal follow-up (CKD)
- KCS (dry eye) → corneal surface disease
- Hip or elbow dysplasia → osteoarthritis
- Diabetes mellitus → cataracts
- Chronic vomiting → diarrhea, pancreatitis, UTI
Attribution
Fang A, Kumar L, Creevy KE, Promislow DE, Ma J, the Dog Aging Project Consortium (2025) Constructing the first comorbidity networks in companion dogs in the Dog Aging Project. PLoS Comput Biol 21(8): e1012728. https://doi.org/10.1371/journal.pcbi.1012728
Data derived from the study’s supplemental tables; reused under CC-BY. Directional pairs are limited to those explicitly supported by literature in the supplement.
See the publication here: Constructing the first comorbidity networks in companion dogs in the Dog Aging Project | PLOS Computational Biology
